Services
The Medicinal Chemistry Core provides a range of services to researchers:
* Provision of tool compounds - the core can identify and source suitable chemical probes, either in small quantities for in vitro testing, or larger amounts for animal studies. If the required compound is not commercially available, the Core can arrange for its custom synthesis. The Gray lab maintains a collection of kinase inhibitors, and also makes available many of its published compounds.
* Medicinal chemistry consulting/advice - the Core can provide input for grant applications, search the chemistry and patent literature for a preliminary assessment of a compound's patentability, and assist with the collection of selectivity, pharmacokinetic and safety data.
* Drug discovery - for researchers pursuing novel therapeutics, or wishing to develop chemical tools for new targets, the Core can assist with hit identification strategies, the analysis and prioritization of HTS data, and the optimization of initial lead molecules for potency, selectivity and pharmacokinetics. With appropriate funding, the Core can more fully collaborate with researchers, designing compounds and synthesizing them, either in its own labs or through a chemistry CRO.
* Provision of tool compounds - the core can identify and source suitable chemical probes, either in small quantities for in vitro testing, or larger amounts for animal studies. If the required compound is not commercially available, the Core can arrange for its custom synthesis. The Gray lab maintains a collection of kinase inhibitors, and also makes available many of its published compounds.
* Medicinal chemistry consulting/advice - the Core can provide input for grant applications, search the chemistry and patent literature for a preliminary assessment of a compound's patentability, and assist with the collection of selectivity, pharmacokinetic and safety data.
* Drug discovery - for researchers pursuing novel therapeutics, or wishing to develop chemical tools for new targets, the Core can assist with hit identification strategies, the analysis and prioritization of HTS data, and the optimization of initial lead molecules for potency, selectivity and pharmacokinetics. With appropriate funding, the Core can more fully collaborate with researchers, designing compounds and synthesizing them, either in its own labs or through a chemistry CRO.